Does Intravenous Thrombolysis Within 4.5 to 9 Hours Increase Clot Migration Leading to Endovascular Inaccessibility?

JC Lim; L Churilov; A Bivard; H Ma; RJ Dowling; BCV Campbell; MW Parsons; SM Davis; GA Donnan; PJ Mitchell; B Yan

Journal article

Does Intravenous Thrombolysis Within 4.5 to 9 Hours Increase Clot Migration Leading to Endovascular Inaccessibility?

JC Lim, L Churilov, A Bivard, H Ma, RJ Dowling, BCV Campbell, MW Parsons, SM Davis, GA Donnan, PJ Mitchell, B Yan

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021

DOI: 10.1161/STROKEAHA.120.030661

Abstract

Background and Purpose: Distal clot migration is a recognized event following intravenous thrombolysis (IVT) in the setting of acute ischemic stroke. Of note, clots that were initially retrievable by endovascular thrombectomy may migrate to a distal nonretrievable location and compromise clinical outcome. We investigated the incidence of clot migration leading to clot inaccessibility following IVT in the time window of 4.5 to 9 hours. Methods: We performed a retrospective analysis of the EXTEND trial (Extending the Time for Thrombolysis in Emergency Neurological Deficits) data. Baseline and 12- to 24-hour follow-up clot location was determined on computed tomography angiogram or magnetic res..

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University of Melbourne Researchers

Leonid Churilov Author

Andrew Bivard Author

Richard Dowling Author

Bruce Campbell Author

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Grants

Funding Acknowledgements

The EXTEND trial (Extending the Time for Thrombolysis in Emergency Neurological Deficits) was supported by grants from the Australian National Health and Medical Research Council of Australia (1043242 and 1035688) and the Commonwealth Scientific and Industrial Research Organization Flagship Program.